Influence of Preload Reduction on Left Ventricular Diastolic Function in Hemodialysis Patients with Left Ventricular Hypertrophy

Objectives: The purpose of this study was to assess how the preload reduction a#ects left ventricular LV diastolic function in hemodialysis patients with LV hypertrophy. Methods: Subjects included 14 patients with LV hypertrophy receiving hemodialysis. The subjects underwent echocardiographic and pulsed Doppler examinations before and after hemodialysis, and the data were analyzed to determine the LV end-diastolic volume EDV and maximal early diastolic transmitral flow velocity E . Similarly, a color M-mode Doppler image of LV filling flow was recorded before and after hemodialysis, and the flow propagation velocity FPV during early LV filling phase was measured. And then, 1 EDV, and FPV E as a parameter of LV diastolic function were compared before and after hemodialysis, 2 the relation between the degree of FPV E FPV E improvement and the degree of EDV EDV decrease was assessed. Results: 1 EDV decreased significantly after hemodialysis p 0.01 , 2 FPV E increased in all of the subjects and increased significantly after hemodialysis compared with before hemodialysis p 0.01 . 3 There was a significant positive correlation between FPV E and EDV r 0.515, p 0.05 . Conclusion:We propose that the preload reduction improves the LV diastolic function in hemodialysis patients with LV hypertrophy, and that this improvement could be dependent on the preload reduction.